Coronavirus

[Bjornebye]

2 minutes ago, Fluter in Dakota said:

Quote from website...

 

Figures include deaths of non-residents.

Based on date a death was registered rather than occurred.

All figures for 2020 are provisional.

The International Classification of Diseases, Tenth Edition (ICD-10) definitions are as follows: coronavirus (COVID-19) (U07.1 and U07.2) and Influenza and Pneumonia (J09-J18).

 

End Quote

 

The numbers reported by ONS with COVID are significantly lower than those reported with pneumomia AND influenza. However I am trying to work out the meaning of this sentence with regards to the figures.

 

Quote from website....

 

A death can be registered with both COVID-19 and Influenza and Pneumonia mentioned on the death certificate. Because pneumonia may be a consequence of COVID-19, deaths where both were mentioned have been counted only in the COVID-19 category. Figures for Influenza and Pneumonia represent where either of these causes have been mentioned anywhere on the death certificate meaning they will not necessarily be the underlying cause of death.

 

The number of deaths registered in Weeks 19, 20, 22 and 23 were impacted by the Early and Late May Bank Holidays (Friday 8 May 2020 in Week 19 and Monday 25 May 2020 in Week 22); the impact of the Early May Bank Holiday was analysed in our week 20 bulletin.

 

End Quote

Ssshhhh you aren’t allowed actual facts ! 

[TheHowieLama]

28 minutes ago, Stront19m Dog™ said:

Happy to help. 

 

Stop pestering El Strontso - he is correct in his isolated statement. More folks are dying right now due to "mentions" of flu. 

 

He is not going to want to talk about the fact that Covid and the "mentions" of flu are just about equal in this calendar year even though there are no recorded deaths for the first three months there for Covid. Which makes it about twice the problem. So, don't.

He is certainly not going to want to discuss All Deaths this calendar year vs the 5 year Average - or even 5 year Maximum. Cuz it's not good.

But - folks gotta make a buck and need someplace to dance and fuck. Can't fault that tbh. 

[Guest]

3 minutes ago, Bjornebye said:

Ssshhhh you aren’t allowed actual facts ! 

 

3 minutes ago, Bjornebye said:

Ssshhhh you aren’t allowed actual facts ! 

Edit: Reading through that, if a death is recorded as influenza/pneumonia this is not necessarily the underlying cause of death - therefore they died with influenza and/or pneumonia. In other words, people dying as a result of flu/pneumonia is not a fact at all, they are dying WITH flu/pneumonia.

[Barrington Womble]

Coronavirus: gatherings of more than six to be banned in England

Government will announce emergency action to strengthen rules and aid police enforcement

• What are you allowed to do from Monday?
• Coronavirus – latest updates
• See all our coronavirus coverage

 

Peter Walker, Simon Murphy

Published:22:18 Tue 8 September 2020

 

The government has announced emergency action to try and stem a feared autumn resurgence of coronavirus, tightening laws to ban virtually all gatherings of more than six people in England.

Amid concerns that the current rules are both widely misunderstood and too difficult for police to implement, Boris Johnson will hold a hastily-arranged Downing Street press conference on Wednesday to outline the new restrictions.

The dramatic change of approach by No 10 follows a sudden spike in the number of people being infected with the virus with almost 8,500 positive tests being recorded in England in the last three days.

On Tuesday ministers added Bolton to the number of cities and towns under local lockdowns restricting restaurants and pubs to takeaways and forcing all venues to close from 10pm to 5am.

Bottlenecks in laboratories processing Covid tests have hampered the government’s attempts to keep on top of the pandemic. The Labour leader, Keir Starmer, warning that the test and trace system is “on the verge of collapse”.

With the government saying delays to tests could take two weeks to address, headteachers and care homes have warned of potential knock-on effects in trying to contain new outbreaks.

Ministers have been increasingly worried that younger people ignoring the rules has helped push the daily rate of positive coronavirus tests in the UK to 2,400 or above for three consecutive days. The fear is that currently low levels of hospital admissions for Covid-19 could also shoot up, as older relatives and other more vulnerable people are infected.

Under current rules for England, guidelines limit most outdoor gatherings to six people, or no more than two households or household bubbles if people are meeting indoors.

The law allows for a higher limit of 30 people, but this is supposed to only be in place for a community event, or a gathering such as a wedding. Up until now the police have had no powers to stop gatherings of up to 30 and ministers believe it has been widely abused.

This will change from Monday to reduce the default maximum to six, making it easier for police to identify and disperse illegal gatherings.

In comments released in advance of the press conference by No 10, Johnson said: “We need to act now to stop the virus spreading. So we are simplifying and strengthening the rules on social contact – making them easier to understand and for the police to enforce.”

Downing Street had hinted at a possible change to the rules, but it had not been expected immediately. The accelerated timetable follows a cabinet meeting on Tuesday morning where Prof Chris Whitty, the chief medical officer for England, and Sir Patrick Vallance, the government’s chief scientific adviser, told ministers that urgent action was needed.

It also comes after an online meeting Johnson held with police forces last week, where officers said they wanted to see simpler rules on social distancing.

The new limit, which comes into effect on Monday, applies across all England and in both private and public spaces, including parks, pubs and restaurants. It also covers all ages, meaning children will be prevented from gathering in larger groups, for example to play informal games of football.

The only exemptions are when households or support bubbles are larger than six people; where gatherings are for work or education purposes; or for weddings, funerals, and organised team sports conducted in a safe way.

Detailed explanations of the changes are yet to be published. For now, rules elsewhere in the UK remain unchanged. In Scotland, gatherings are limited to five households outdoors, or three households indoors. In Wales, the outdoor limit is still 30, but indoors people are discouraged from all contact with people outside their household.

In parallel with Johnson’s press conference, the government will launch a new public information campaign on Wednesday to reiterate messaging on handwashing and mask use.

It follows new rules for Bolton unveiled by Matt Hancock, the health secretary, which means that guidance barring people from socialising outside of their households will also be made law.

There are an average of 120 Covid-19 cases per 100,000 of the population in Bolton, meaning it has the highest rate in the country. The rise in Bolton is “partly due to socialising by people in their 20s and 30s”, Hancock told the Commons, explaining that contact tracers had identified a number of pubs where the virus had spread.

Unveiling the measures which will be imposed immediately, Hancock said: “We will restrict all hospitality to takeaway only, and will introduce a late night restriction of operating hours which will mean all venues will be required to close from 10pm to 5am.

“We’ll introduce urgently further measures that put the current guidance that people cannot socialise outside their household into law.”

Bolton council said on Saturday it was introducing tougher measures “with immediate effect”, asking people not to mix with other households in any setting, either indoors or outdoors, and to only use public transport for essential purposes.

The Conservative leader of Bolton Council, councillor David Greenhalgh, said the measures were “not something we want to do but it is clear the virus is currently moving round the borough uncontrolled and so we need to halt the transmission rate”.

“The rate has gone from 15 cases per 100,000 to over 120 in the space of two weeks, and if we do not get control of the virus now we will continue to put our most vulnerable residents at risk and delay any return to normality,” he said.

Leaders across much of northern England on Tuesday pleaded with residents to “do their bit” to avoid further lockdown measures. Representatives of every local authority in the north-east wrote an open letter to lambast the “significant minority” of residents having house parties and ignoring the rules, saying they were “deeply concerned” at the increasing number of positive coronavirus cases, particularly among young adults.

[Strontium]

10 minutes ago, Barrington Womble said:

Coronavirus: gatherings of more than six to be banned in England

Government will announce emergency action to strengthen rules and aid police enforcement

• What are you allowed to do from Monday?
• Coronavirus – latest updates
• See all our coronavirus coverage

 

Peter Walker, Simon Murphy

Published:22:18 Tue 8 September 2020

 

The government has announced emergency action to try and stem a feared autumn resurgence of coronavirus, tightening laws to ban virtually all gatherings of more than six people in England.

Amid concerns that the current rules are both widely misunderstood and too difficult for police to implement, Boris Johnson will hold a hastily-arranged Downing Street press conference on Wednesday to outline the new restrictions.

The dramatic change of approach by No 10 follows a sudden spike in the number of people being infected with the virus with almost 8,500 positive tests being recorded in England in the last three days.

On Tuesday ministers added Bolton to the number of cities and towns under local lockdowns restricting restaurants and pubs to takeaways and forcing all venues to close from 10pm to 5am.

Bottlenecks in laboratories processing Covid tests have hampered the government’s attempts to keep on top of the pandemic. The Labour leader, Keir Starmer, warning that the test and trace system is “on the verge of collapse”.

With the government saying delays to tests could take two weeks to address, headteachers and care homes have warned of potential knock-on effects in trying to contain new outbreaks.

Ministers have been increasingly worried that younger people ignoring the rules has helped push the daily rate of positive coronavirus tests in the UK to 2,400 or above for three consecutive days. The fear is that currently low levels of hospital admissions for Covid-19 could also shoot up, as older relatives and other more vulnerable people are infected.

Under current rules for England, guidelines limit most outdoor gatherings to six people, or no more than two households or household bubbles if people are meeting indoors.

The law allows for a higher limit of 30 people, but this is supposed to only be in place for a community event, or a gathering such as a wedding. Up until now the police have had no powers to stop gatherings of up to 30 and ministers believe it has been widely abused.

This will change from Monday to reduce the default maximum to six, making it easier for police to identify and disperse illegal gatherings.

In comments released in advance of the press conference by No 10, Johnson said: “We need to act now to stop the virus spreading. So we are simplifying and strengthening the rules on social contact – making them easier to understand and for the police to enforce.”

Downing Street had hinted at a possible change to the rules, but it had not been expected immediately. The accelerated timetable follows a cabinet meeting on Tuesday morning where Prof Chris Whitty, the chief medical officer for England, and Sir Patrick Vallance, the government’s chief scientific adviser, told ministers that urgent action was needed.

It also comes after an online meeting Johnson held with police forces last week, where officers said they wanted to see simpler rules on social distancing.

The new limit, which comes into effect on Monday, applies across all England and in both private and public spaces, including parks, pubs and restaurants. It also covers all ages, meaning children will be prevented from gathering in larger groups, for example to play informal games of football.

The only exemptions are when households or support bubbles are larger than six people; where gatherings are for work or education purposes; or for weddings, funerals, and organised team sports conducted in a safe way.

Detailed explanations of the changes are yet to be published. For now, rules elsewhere in the UK remain unchanged. In Scotland, gatherings are limited to five households outdoors, or three households indoors. In Wales, the outdoor limit is still 30, but indoors people are discouraged from all contact with people outside their household.

In parallel with Johnson’s press conference, the government will launch a new public information campaign on Wednesday to reiterate messaging on handwashing and mask use.

It follows new rules for Bolton unveiled by Matt Hancock, the health secretary, which means that guidance barring people from socialising outside of their households will also be made law.

There are an average of 120 Covid-19 cases per 100,000 of the population in Bolton, meaning it has the highest rate in the country. The rise in Bolton is “partly due to socialising by people in their 20s and 30s”, Hancock told the Commons, explaining that contact tracers had identified a number of pubs where the virus had spread.

Unveiling the measures which will be imposed immediately, Hancock said: “We will restrict all hospitality to takeaway only, and will introduce a late night restriction of operating hours which will mean all venues will be required to close from 10pm to 5am.

“We’ll introduce urgently further measures that put the current guidance that people cannot socialise outside their household into law.”

Bolton council said on Saturday it was introducing tougher measures “with immediate effect”, asking people not to mix with other households in any setting, either indoors or outdoors, and to only use public transport for essential purposes.

The Conservative leader of Bolton Council, councillor David Greenhalgh, said the measures were “not something we want to do but it is clear the virus is currently moving round the borough uncontrolled and so we need to halt the transmission rate”.

“The rate has gone from 15 cases per 100,000 to over 120 in the space of two weeks, and if we do not get control of the virus now we will continue to put our most vulnerable residents at risk and delay any return to normality,” he said.

Leaders across much of northern England on Tuesday pleaded with residents to “do their bit” to avoid further lockdown measures. Representatives of every local authority in the north-east wrote an open letter to lambast the “significant minority” of residents having house parties and ignoring the rules, saying they were “deeply concerned” at the increasing number of positive coronavirus cases, particularly among young adults.

 

Hahahahaha. 

 

Boris Johnson: How am I doing boss?

Adolf Hitler: Steady on fella, it's a bit much isn't it?

[Special K]

Lucky those who bought tickets to the St Leger can still go innit?

[Megadrive Man]

41 minutes ago, Stront19m Dog™ said:

 

There doesn't seem to be any overarching idea to any of this. It's apparently not enough that covid is killing virtually nobody and is far less lethal than the dozens of other causes of death with which we coexist normally, for us to go back to normal. So I can only conclude that we'll be labouring under these hellish conditions until it's eradicated completely, which may be never.

 

The word 'if' is doing a lot of heavy lifting in your second sentence. 

 

I would hardly describe having to wear a mask, socially distance and put some screens up as labouring under hellish conditions!

 

I'm not overly convinced that any of these things make a huge difference, but i'm happy to give it a go with a view that it may help to slow it down. If it doesn't, no harm done.

 

[Nelly-Szoboszlai]

The AstraZeneca vaccine trial has been temporarily suspended due to a participant suffering from an unexpected illness. 

 

https://mobile.twitter.com/thehill/status/1303457144700887048

[Gnasher]

11 minutes ago, MegadriveMan said:

 

I would hardly describe having to wear a mask, socially distance and put some screens up as labouring under hellish conditions!

 

I'm not overly convinced that any of these things make a huge difference, but i'm happy to give it a go with a view that it may help to slow it down. If it doesn't, no harm done.

 

That's pretty much where I am, I wear a mask and social distance even though I think the threat of dying of covid is overplayed.

[Guest Alex_K]

1 hour ago, Stront19m Dog™ said:

 

Hahahahaha. 

 

Boris Johnson: How am I doing boss?

Adolf Hitler: Steady on fella, it's a bit much isn't it?

Yep. What an absolute farce.

[Megadrive Man]

At least by delaying it until Monday, people can all get together and have a big blow out over the weekend. Smart.

[Champ]

 

2 hours ago, MegadriveMan said:

At least by delaying it until Monday, people can all get together and have a big blow out over the weekend. Smart.

These delays before introducing restrictions like this make no sense at all to me

[Bobby Hundreds]

Does this mean pubs shutting again, pubs allowing only 6 people in or groups of  6 can sit together sewerage from another group of 6. This is all ridiculous.

 

 

[chrisbonnie]

6 hours ago, Nelly-Torres said:

The AstraZeneca vaccine trial has been temporarily suspended due to a participant suffering from an unexpected illness. 

 

https://mobile.twitter.com/thehill/status/1303457144700887048

 

The good news just keeps coming doesn't it. 

 

Fuck me, will this ever end.............. 

[Guest]

7 hours ago, Stront19m Dog™ said:

 

Hahahahaha. 

 

Boris Johnson: How am I doing boss?

Adolf Hitler: Steady on fella, it's a bit much isn't it?

He's not even trying to look like he gives a fuck anymore.

[Stickman]

 

[Stickman]

 

8 hours ago, Barrington Womble said:

Coronavirus: gatherings of more than six to be banned in England

 

 

 

15 hours ago, Stickman said:

Just when things can’t get any worse...

 

 

@SkyNews

Steps announce comeback with new album and tour

https://news.sky.com/story/steps-announce-comeback-with-new-album-and-tour-12066465

 

 

It's not all doom and gloom at least that rules out S Club 7 reforming.....

[Barrington Womble]

1 hour ago, Bobby Hundreds said:

Does this mean pubs shutting again, pubs allowing only 6 people in or groups of  6 can sit together sewerage from another group of 6. This is all ridiculous.

 

 

I genuinely don't know what this means. Or at least how it's different. I thought we were supposed to already have these restrictions? When I've been the pub in large numbers they've forced people to sit in small groups and you can't move tables or stand up. But it seems that's what the new rules mean.

[Davelfc]

I suddenly have the urge to buy a shit load of toilet rolls. 

[Mudface]

48 minutes ago, Stickman said:

 

 

[Barrington Womble]

Astrazenica trial put on hold. Sorry if it was posted before. 

 

https://www.statnews.com/2020/09/08/astrazeneca-covid-19-vaccine-study-put-on-hold-due-to-suspected-adverse-reaction-in-participant-in-the-u-k/

 

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EXCLUSIVE

AstraZeneca Covid-19 vaccine study put on hold due to suspected adverse reaction in participant in the U.K.

By REBECCA ROBBINS @rebeccadrobbins, ADAM FEUERSTEIN @adamfeuerstein, and HELEN BRANSWELL @HelenBranswell

SEPTEMBER 8, 2020

Reprints

 

KIRSTY WIGGLESWORTH/AP

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Alarge, Phase 3 study testing a Covid-19 vaccine being developed by AstraZeneca and the University of Oxford at dozens of sites across the U.S. has been put on hold due to a suspected serious adverse reaction in a participant in the United Kingdom.

A spokesperson for AstraZeneca, a frontrunner in the race for a Covid-19 vaccine, said in a statement that the company’s “standard review process triggered a pause to vaccination to allow review of safety data.” 

In a follow-up statement, AstraZeneca said it initiated the study hold. The nature of the adverse reaction and when it happened were not immediately known, though the participant is expected to recover, according to an individual familiar with the matter. 

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The spokesperson described the pause as “a routine action which has to happen whenever there is a potentially unexplained illness in one of the trials, while it is investigated, ensuring we maintain the integrity of the trials.” The spokesperson also said that the company is “working to expedite the review of the single event to minimize any potential impact on the trial timeline.”

An individual familiar with the development said researchers had been told the hold was placed on the trial out of “an abundance of caution.” A second individual familiar with the matter, who also spoke on condition of anonymity, said the finding is having an impact on other AstraZeneca vaccine trials underway — as well as on the clinical trials being conducted by other vaccine manufacturers.

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Related: 

‘An unchartered situation for all of us’: From shipping containers to security concerns, a Covid-19 vaccine supply chain takes shape

Clinical holds are not uncommon, and it’s unclear how long AstraZeneca’s might last. But the progress of the company’s trial — and those of all Covid-19 vaccines in development — are being closely watched given the pressing need for new ways to curb the global pandemic. There are currently nine vaccine candidates in Phase 3 trials. AstraZeneca’s is the first Phase 3 Covid-19 vaccine trial known to have been put on hold.

Researchers running other trials are now looking for similar cases of adverse reactions by combing through databases reviewed by a so-called Data and Safety Monitoring Board, the second person said.

AstraZeneca only began its Phase 3 trial in the U.S. in late August. The U.S. trial is currently taking place at 62 sites across the country, according to clinicaltrials.gov, a government registry, though some have not yet started enrolling participants. Phase 2/3 trials were previously started in the U.K., Brazil, and South Africa.

There are a number of different reactions that can qualify as suspected serious adverse reactions, symptoms that require hospitalization, life-threatening illness and even death. It was also not immediately clear which clinical trial the adverse reaction occurred in, though a clear possibility is the Phase 2/3 trial underway in the U.K.

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While it’s still unclear how severe and rare the adverse event may be, the finding could impact how quickly efficacy data from the U.K. trial will be available. Those data are considered integral to any bid to seek an emergency use authorization for the vaccine from the U.S. Food and Drug Administration — and potentially jeopardize President Trump’s efforts to fast-track a vaccine ahead of the November election.

A Phase 1/2 study published in July reported that about 60% of 1,000 participants given the vaccine experienced side effects. All of the side effects, which included fever, headaches, muscle pain, and injection site reactions, were deemed mild or moderate. All of the side effects reported also subsided during the course of the study. 

The vaccine  — known as AZD1222 — uses an adenovirus that carries a gene for one of the proteins in SARS-CoV-2, the virus that causes Covid-19. The adenovirus is designed to induce the immune system to generate a protective response against SARS-2. The platform has not been used in an approved vaccine, but has been tested in experimental vaccines against other viruses, including the Ebola virus. 

The Phase 3 trial in the U.S. aims to enroll about 30,000 participants at 80 sites across the country, according to a release last week from the National Institutes of Health. 

It was not immediately clear what steps were being taken at study sites across the U.S. in response to the hold. Clinical holds in ongoing studies often involve a pause in recruiting new participants and dosing existing ones, unless it’s deemed in the interest of participant safety to continue dosing.

In the statement from AstraZeneca, the company spokesperson noted that “in large trials illnesses will happen by chance but must be independently reviewed to check this carefully.” The spokesperson also said the company is “committed to the safety of our participants and the highest standards of conduct in our trials.”

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About the AuthorsReprints

Rebecca Robbins

San Francisco Correspondent

Rebecca covers the life sciences industry in the Bay Area. She is the co-author of the newsletter STAT Health Tech.

 

 rebecca.robbins@statnews.com

 

 @rebeccadrobbins

Adam Feuerstein

Senior Writer, Biotech

Adam is STAT’s national biotech columnist, reporting on the intersection of biotech and Wall Street.

 

 adam.feuerstein@statnews.com

 

 @adamfeuerstein

Helen Branswell

Senior Writer, Infectious Disease

Helen covers issues broadly related to infectious diseases, including outbreaks, preparedness, research, and vaccine development.

 

 @HelenBranswell

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[chrisbonnie]

Fingers crossed the illness the volunteer has is not related to the vaccine.

 

If it is which again I hope its not, the Oxford vaccine isn't the only one in development, so it's not like all our eggs are in one basket. 

[Section_31]

1 minute ago, chrisbonnie said:

Fingers crossed the illness the volunteer has is not related to the vaccine.

 

If it is which again I hope its not, the Oxford vaccine isn't the only one in development, so it's not like all our eggs are in one basket. 

Cambridge coming up on the outside.

[Bobby Hundreds]

3 hours ago, Bobby Hundreds said:

Does this mean pubs shutting again, pubs allowing only 6 people in or groups of  6 can sit together sewerage from another group of 6. This is all ridiculous.

 

 

Separate not sewerage!

 

Must just be harsher fines for people breaking the current rules or actually policing it.

[Barrington Womble]

11 minutes ago, chrisbonnie said:

Fingers crossed the illness the volunteer has is not related to the vaccine.

 

If it is which again I hope its not, the Oxford vaccine isn't the only one in development, so it's not like all our eggs are in one basket. 

I guess the issue is we've been led to believe about the accelerated path we are on to get the vaccine quickly is not as straight forward as people would have us believe. It would look reading that article this is a pretty normal event, but normal is a much longer cycle than everyone is hoping for.