Jenson

It doesn't have a proper pull up lever handbrake by the gearstick, instead it has a handle on the right hand side of the steering wheel that you push in to put the handbrake on and pull out to take it off. It's all kinds of wrong.

One of the things to consider with the spike protein mutating is that it cannot continue indefinitely. The spike protein is the binding protein that the virus uses to latch onto the ACE2 receptor expressed by our cells, allowing the virus to enter the cell and cause infection. The efficiency of binding is what determines how infectious the virus is, and a lot of the mutations we are seeing now are increasing this binding efficiency. These mutations are also changing the genetic code that the vaccines are designed to target and so could reduce vaccine efficacy. However, as soon as the spike protein reaches optimal binding efficiency, any more mutations will, by definition, reduce binding, and these mutations will therefore not propogate in the general viral population. At this point, the spike protein genetic code essentially becomes static, which would (hopefully) remove the problem of the virus becoming resistent to antibodies produced by the vaccine(s).

I hate the keyless start button on my girlfriends car and just absolutely cannot get used to the fact that it doesn't have a proper handbrake.

I'm 48 this year, the other half is 6 years younger, and her sex drive is way higher than mine. I struggle manfully to keep up but more often than not I would kill for a nice cup of tea.

This is exactly what they are doing. Easter provides a natural circuit breaker in order to assess the effects of kids going back to school.

Fair play to Rice Krispie head, he's been banging on about how utterly shit VAR is for a while.

Have they started bigging themselves up for Saturday yet? That's always a good sign.

@Bruce Spanner This is from the Preliminary report from the Joint PHE Porton Down & University of Oxford SARS-CoV-2 test development and validation cell: Rapid evaluation of Lateral Flow Viral Antigen detection devices (LFDs) for mass community testing, which I think supports both our viewpoints - "To date, the performance characteristics of the Innova LFD in the evaluations performed to date are good with a low failure rate, high specificity 99.6% and high viral antigen detection. Furthermore, issues need to be addressed to understand batch to batch variation, acceptance of the tests by the general publicand the effect of operator/training effects upon performance characteristics. The delivery of appropriate training appears important to test performance. It is important to note the possibility that performance of these tests may improve with time as more research is performed within phase 4 evaluations. LFD implementation may offer advantages in national testing strategies focusing on risk reduction and warrant further testing in mass-testing scenarios.It also promises a massive increasein testing by enabling a distributed community-based use separate fromthe overburdened national and NHS testing laboratories." https://www.ox.ac.uk/sites/files/oxford/media_wysiwyg/UK evaluation_PHE Porton Down University of Oxford_final.pdf

I think 10K will probably be my limit. I'm pretty fit through playing football but that's a different kind of fitness and I've never been much of an endurance runner. However with no football on the horizon in the near future, I need to be out doing something. I'll be pretty bloody ecstatic if I can get below an hour.

Which is fair comment, but it's not right to dismiss the tests themselves as 'useless' or 'unreliable', as when used correctly they're pretty good.

I'm currently on 64 minutes for 10K, but slowly working the time down.

Depends on what you mean by not reliable. Used in the right way, the lateral flow tests can be a useful tool.

Has any team fallen off a cliff quite so spectacularly as we have? We were top at Christmas!!

A bit more flesh to the bone: https://www.nature.com/articles/d41586-021-00316-4 Israel are using the Pfizer vaccine exclusively so it will be interesting to see the data in the UK with the AZ vaccine

No fans has fucked us more than any team in the league by far. Jamie Redknapp was spot on, Anfield right now is just a grass pitch with four empty stands around it. WE are Anfield and without us its nothing.

We need fans back asap

It's a dark day when you're agreeing with both Micah Richards and Jamie Redknapp at the same time.

My divorce has given me a new lease of life. It was the most painful time of my life and cost me a shit load of money, but now I'm through that I can see that it was absolutely the right thing to happen. I've been with my girlfriend for the best part of 3 and a half years and my relationship with her is a million times better than what my marriage became. Pre-lockdown I got back to playing and watching f***y with my mates, went skiing with the lads and became myself again. I miss my daughters when they're not with me of course but I see them on a weekly basis and it's proper quality time. Onwards and upwards as they say.

Sorry mate, but not one word of that makes any scientific sense at all

In terms of vaccine efficacy, 60% is still pretty good.

Son is going to get through about half a dozen times tonight

Always loved VAR

Didn't see that coming at all

I said this before but the lack of fans in the ground is hampering us so much, more so than any other team in the league right now. 75,000 mancs screaming abuse at them yesterday would have seen the team pumped up to fuck. Playing a League 2 standard centre half obviously doesn't help either.