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2 hours ago, Brownie said:

I don't agree to be honest. If pubs are open and have protocols in place then I don't think people are cunts for going.

It's a hugely sanitised experience now, one that's very hard to enjoy. 

Obviously a few pubs will resist and want to offer a 'normal' experience to their punters, but that will only work with small boozers with a handful of locals. 

 

I think ultimately pubs will return to something akin to normal this summer. There isn't enough enforcement resource to seriously expect anything else.  

 

Personally I'll still be swerving them until I've had the jab, unless there's a pub with a strong outdoor set-up. 

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Loads of pubs here threatening to open on Tuesday. They bottled it last time they gave an ultimatum so we shall see. Bizarrely, this time there's a load of sex workers saying that they are also going to open for business. 

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1 minute ago, cloggypop said:

Loads of pubs here threatening to open on Tuesday. They bottled it last time they gave an ultimatum so we shall see. Bizarrely, this time there's a load of sex workers saying that they are also going to open for business. 

 

What's the support package like over there?

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2 minutes ago, Bruce Spanner said:

 

What's the support package like over there?

They've just given businesses more. Can't remember how much. 

 

It's elections next month though. 

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I really don't understand why they gave the 21st June date as a date to lift all restricitions. It has just made a lot of people think they don't need to carry on acting sensibly and doing what we have been and is if come 21st June Covid will not exist, I mean for fucks sake there is a petiton to make that date a bank holiday so we can all get together and have a knees up and a cuddle because it will be safe to do so from that day.

They could have quite easily done the roadmap without that date and just seen what happens 5 weeks after the pubs were opened; I mean there will be a lot of people who won't social distance like they would in the pub simply because they believe the government has told them Covid is on its arse and will be gone in 5 weeks so whats the difference. 

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1 hour ago, Rico1304 said:

It’s all the lap dancers I feel sorry for. 

I matched one on Tinder last summer and had some profound conversations with her about life, the universe and her double-ended dildo. Ended up arranging for her to do a Zoom stag night for a friend of a friend. I didn’t get a cut, I’m not Iceberg Slim. Only Fans must be doing a roaring trade from them all, she was setting one up last I spoke to her.

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13 hours ago, Barrington Womble said:

that's the immediate problem yes. 

 

but the more the virus circulates, the more opportunity there is for mutations and new variants. 

 

the more mutations and new variants, the more chance we end up with a vaccine resistant strain. 

 

so controlling things while understanding transmissibility seems to me to make perfect sense. i am not smart enough to know how they calculate that transmissibility as it depends on so many factors, including peoples behaviour. 

 

16 hours ago, Rico1304 said:

Because they aren’t sure YET that it stops transmission.  They’ve proved it reduces the severity but that’s it so far.  

 

Fair enough, hadn't considered mutations, and its a good point.

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16 hours ago, 3 Stacks said:

If someone is vaccinated, and loads of the population are as well, I don't see why they shouldn't go to the pub. And my point is, that's what we should be telling people to encourage them. 

There are 55 million adults and teenagers in the UK (15 and over) and 18 million have been vaccinated. That's still a deficit of 37 million people.

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Just woke up and seen this tread had gone up five pages over night. I thought there must have been a really interesting development taken place, some good reading ahead. I was wrong.

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23 minutes ago, Champ said:

Would thoroughly recommend BBC’s Horizons last night for an exploration of the understanding of the virus and the development of the vaccines. Proper science

 

https://www.bbc.co.uk/programmes/m000slmx

In this third Horizon special, Dr Chris Van Tulleken is joined by his brother Xand and Dr Guddi Singh to take us through the latest developments and answer current concerns.

 

That's an uninspiring line up. They'd get loads more viewers if it was narrated by Danny Baker, with reminiscences from Jonathon Ross, Claudia Winkleman and Andy Flintoff about last March's lockdown.

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5 minutes ago, Mudface said:

 

 

 

That's an uninspiring line up. They'd get loads more viewers if it was narrated by Danny Baker, with reminiscences from Jonathon Ross, Claudia Winkleman and Andy Flintoff about last March's lockdown.

It was like the Horizons/Panorama of my youth/memory. Proper, detailed scientific explanation 

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2 minutes ago, Champ said:

It was like the Horizons/Panorama of my youth/memory. Proper, detailed scientific explanation 

And no cranks with an 'alternative' viewpoint given equal airtime in a ridiculous attempt at 'balance'?

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One of the things to consider with the spike protein mutating is that it cannot continue indefinitely.

 

The spike protein is the binding protein that the virus uses to latch onto the ACE2 receptor expressed by our cells, allowing the virus to enter the cell and cause infection.

 

The efficiency of binding is what determines how infectious the virus is, and a lot of the mutations we are seeing now are increasing this binding efficiency. These mutations are also changing the genetic code that the vaccines are designed to target and so could reduce vaccine efficacy.

 

However, as soon as the spike protein reaches optimal binding efficiency, any more mutations will, by definition, reduce binding, and these mutations will therefore not propogate in the general viral population.

 

At this point, the spike protein genetic code essentially becomes static, which would (hopefully) remove the problem of the virus becoming resistent to antibodies produced by the vaccine(s).

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1 hour ago, Champ said:

It was like the Horizons/Panorama of my youth/memory. Proper, detailed scientific explanation 

What did Nigel Farage have to say? 

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1 hour ago, Jenson said:

One of the things to consider with the spike protein mutating is that it cannot continue indefinitely.

 

The spike protein is the binding protein that the virus uses to latch onto the ACE2 receptor expressed by our cells, allowing the virus to enter the cell and cause infection.

 

The efficiency of binding is what determines how infectious the virus is, and a lot of the mutations we are seeing now are increasing this binding efficiency. These mutations are also changing the genetic code that the vaccines are designed to target and so could reduce vaccine efficacy.

 

However, as soon as the spike protein reaches optimal binding efficiency, any more mutations will, by definition, reduce binding, and these mutations will therefore not propogate in the general viral population.

 

At this point, the spike protein genetic code essentially becomes static, which would (hopefully) remove the problem of the virus becoming resistent to antibodies produced by the vaccine(s).

but unless i misunderstand the process, that is not likely to happen any time soon is it? 

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